Rebeccamycin 是一种抗肿瘤抗生素，可抑制 DNA 拓扑异构酶 I。Rebeccamycin 似乎通过毒化拓扑异构酶 I 发挥其主要的抗肿瘤作用，而对蛋白激酶 C 和拓扑异构酶 II 的影响可忽略不计。
| Cas No. | 93908-02-2 |
| 别名 | 蝴蝶霉素 |
| Canonical SMILES | O=C(NC1=O)C2=C1C(C(C=CC=C3Cl)=C3N4[C@]5([H])O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]5O)=C4C6=C2C7=C(C(Cl)=CC=C7)N6 |
| 分子式 | C27H21Cl2N3O7 |
| 分子量 | 570.4 |
| 溶解度 | DMF: Soluble,DMSO: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells. |
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