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N-desmethyl Bendamustine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Bendamustine图片
CAS NO:41515-13-3
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine.
Cas No.41515-13-3
别名盐酸苯达莫司汀乙酯水解杂质
Canonical SMILESClCCN(CCCl)C1=CC=C(N=C(CCCC(O)=O)N2)C2=C1
分子式C15H19Cl2N3O2
分子量344.2
溶解度Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine . N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).