| CAS NO: | 175892-43-0 |
| 包装: | 1mg |
| 市场价: | 3175元 |
| Cas No. | 175892-43-0 |
| Canonical SMILES | OC[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCC)=O |
| 分子式 | C26H51NO3 |
| 分子量 | 425.7 |
| 溶解度 | Chloroform: Soluble,DMF: Soluble,DMSO: Soluble,Ethanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml. |
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