| CAS NO: | 1492-18-8 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| Cas No. | 1492-18-8 |
| 别名 | 亚叶酸钙; Leucovorin calcium; Calcium folinate |
| 化学名 | N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, monocalcium salt |
| Canonical SMILES | O=CN1C(CNC2=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C2)CNC3=C1C(N=C(N)N3)=O.[Ca+2] |
| 分子式 | C20H21N7O7o Ca |
| 分子量 | 511.5 |
| 溶解度 | Water: 0.3 mg/ml |
| 储存条件 | 4°C, protect from light ,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1]. MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1]. Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. References: |
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