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PD 0332991-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD 0332991-d8图片
CAS NO:1628752-83-9
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
Palbociclib D8 (PD 0332991 D8) 是一种氘标记的 Palbociclib。 Palbociclib 是一种选择性和口服活性的 CDK4 和 CDK6 抑制剂,IC50 分别为 11 和 16 nM。 Palbociclib 具有用于 ER 阳性和 HER2 阴性乳腺癌研究的潜力。
Cas No.1628752-83-9
别名帕博西尼-D8,PD 0332991-d8
Canonical SMILESO=C1N(C2CCCC2)C3=NC(NC4=NC=C(N5C([2H])([2H])C([2H])([2H])NC([2H])([2H])C5([2H])[2H])C=C4)=NC=C3C(C)=C1C(C)=O
分子式C24H21D8N7O2
分子量455.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PD 0332991-d8 is intended for use as an internal standard for the quantification of PD 0332991 by GC- or LC-MS. PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclin D1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.