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GSK2643943A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2643943A图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GSK2643943A是一种去泛素化酶(DUB)的抑制剂,其对USP20/Ub-Rho的IC50值为160nM.
Canonical SMILESFC1=CC=CC(/C=C/C2=CC(NC(N)=C3C#N)=C3C=C2)=C1
分子式C17H12FN3
分子量277.3
溶解度DMSO : ≥ 125 mg/mL (450.78 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC50 of 160 nM for USP20/Ub-Rho.

[1]. "Harrigan JA, et al.Deubiquitylating enzymes and drug discovery: emerging opportunities.Nat Rev Drug Discov. 2018 Jan;17(1):57-78." [2]. Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer