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Acyclovir-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acyclovir-d4图片
CAS NO:1185179-33-2
包装:1mg
市场价:3311元

产品介绍
An internal standard for the quantification of acyclovir
Cas No.1185179-33-2
别名阿昔洛韦D4,Aciclovir-d4; Acycloguanosine-d4
Canonical SMILESO=C1C2=C(N(COC([2H])([2H])C([2H])([2H])O)C=N2)N=C(N)N1
分子式C8H7D4N5O3
分子量229.2
溶解度DMSO: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Acyclovir-d4is intended for use as an internal standard for the quantification of acyclovir by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activityin vitroagainst the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).1It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.2Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.3

1.Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev.Infect.Dis.12(Suppl. 7)S849-S860(1990) 2.Bean, B.Antiviral therapy: Current concepts and practicesClin.Microbiol.Rev.5(2)146-182(1992) 3.Ashton, R.J., Abbott, K.H., Smith, G.M., et al.Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16J. Antimicrob. Chemother.34(2)287-290(1994)