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Abametapir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abametapir图片
CAS NO:1762-34-1
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Abametapir 是一种金属蛋白酶 (MMP) 抑制剂,能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
Cas No.1762-34-1
别名55'-二甲基-2,2-联吡啶
Canonical SMILESCC1=CC=C(C2=CC=C(C)C=N2)N=C1
分子式C12H12N2
分子量184.2
溶解度DMF: 15mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
储存条件4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Abametapir is a building block and an insectide.1,2,3It has been used in the synthesis of lanthanide coordination complexes with antifungal activity againstC. albicansand divalent vancomycin derivatives with antibacterial activity against vancomycin-resistant enterococci.1,2Abametapir is ovicidal to DDT- and permethrin-resistant head louse eggs (LC50s = 0.108, 0.121, and 0.16% in isopropanol for 0-2-, 3-5-, and 6-8-day-old eggs, respectively).3Formulations containing abametapir have been used in the topical treatment of head lice infestation.

1.Zhou, M.-X., Ren, N., Zhang, J.-J., et al.Synthesis, crystal structure, thermal, luminescent property and antibacterial activity of lanthanide ternary complexes with p-chlorobenzoic acid and 5,5′-dimethyl-2,2′-bipyridineJ. Mol. Struct.1200127049(2020) 2.Xing, B., Yu, C.-W., Ho, P.-L., et al.Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococciJ. Med. Chem.46(23)4904-4909(2003) 3.Bowles, V.M., Yoon, K.S., Barker, S.C., et al.Ovicidal efficacy of abametapir against eggs of human head and body lice (Anoplura: Pediculidae)J. Med. Entomol.54(1)167-172(2017)