CAS NO: | 24449-39-6 |
包装: | 1mg |
市场价: | 1170元 |
Cas No. | 24449-39-6 |
别名 | 乌楠酚 |
Canonical SMILES | OC1=C(C=CC=C2)C2=C(O3)C(C=CC3(C)C)=C1C4=C(C=CC5(C)C)C(O5)=C6C(C=CC=C6)=C4O |
分子式 | C30H26O4 |
分子量 | 450.53 |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2]. [1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795. [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107. |