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Tectol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tectol图片
CAS NO:24449-39-6
包装:1mg
市场价:1170元

产品介绍
Tectol,从Lippiasidoides中分离,对人白血病细胞株HL60和CEM具有显著的抑制作用。Tectol是一种farnesyltransferase(FTase)抑制剂,在人和布氏锥虫的IC50分别为2.09和1.73μM。Tectol抑制耐药恶性疟原虫(FcB1),IC50为3.44μM。
Cas No.24449-39-6
别名乌楠酚
Canonical SMILESOC1=C(C=CC=C2)C2=C(O3)C(C=CC3(C)C)=C1C4=C(C=CC5(C)C)C(O5)=C6C(C=CC=C6)=C4O
分子式C30H26O4
分子量450.53
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795. [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.