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Mertansine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mertansine图片
CAS NO:139504-50-0
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Mertansine (DM1) 是一种微管蛋白抑制剂,是一种可偶联抗体的类美登素,旨在克服与美登素相关的全身毒性并增强肿瘤特异性递送。 Mertansine 可以通过接头连接到单克隆抗体上,以产生抗体-药物偶联物 (ADC)。
Cas No.139504-50-0
别名美登素,DM1; Maytansinoid DM1
Canonical SMILESC[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCS)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1
分子式C35H48ClN3O10S
分子量738.29
溶解度DMSO : ≥ 83.33 mg/mL (112.87 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

References:
[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.