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TN-16
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TN-16图片
CAS NO:33016-12-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
TN-16 是一种有效的微管聚合抑制剂,IC50 为 0.4-1.7 μM。
Cas No.33016-12-5
化学名3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione
Canonical SMILESO=C(/C1=C(C)\NC2=CC=CC=C2)NC(CC3=CC=CC=C3)C1=O
分子式C19H18N2O2
分子量306.4
溶解度DMF: 12.5 mg/mL,DMSO: 20 mg/mL,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL,Ethanol: 0.25 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). It blocks taxol-induced assembly of tubulin (IC50 = 6 uM) and blocks colchicine binding to tubulin. Like colchicine, TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells. TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.