Fascaplysin (chloride) 是一种抗菌和具有细胞毒性的红色色素，可以来自海绵 (Fascaplysin (chloride)opsis sp.
| Cas No. | 114719-57-2 |
| 化学名 | 12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium, monochloride |
| Canonical SMILES | O=C1C2=[N+](C=CC3=C2C4=C(C=CC=C4)N3[H])C5=CC=CC=C51.[Cl-] |
| 分子式 | C18H11N2O.Cl |
| 分子量 | 306.8 |
| 溶解度 | DMF: 0.14 mg/mL,DMSO: 16 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM) that was originally isolated from the marine sponge Thorectandra. It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does not inhibit other Cdks and tyrosine kinases. Fascaplysin is reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest. Inhibition of Cdk4 via fascaplysin has been shown to induce peroxisome-proliferator-activated receptor γ-1α deacetylation (IC50 = 0.7 uM) and has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism. |
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