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Alternariol monomethyl ether
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alternariol monomethyl ether图片
CAS NO:23452-05-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Alternariol monomethyl ether 分离自 Anthocleista djalonensis (Loganiaceae) 的根,是该植物物种的重要分类标记。
Cas No.23452-05-3
别名交链孢霉甲基醚
化学名3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
Canonical SMILESCC1=C(C2=C(C(O3)=O)C(O)=CC(OC)=C2)C3=CC(O)=C1
分子式C15H12O5
分子量272.3
溶解度Dichloromethane: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells). It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM). AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.