| Cas No. | 120533-76-8 |
| 别名 | DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC" |
| 化学名 | 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester |
| Canonical SMILES | O=C(OCC)C1=CN(CC2=CC=CC=C2)C=C(C(OCC)=O)C1C3=CC=CC=C3 |
| 分子式 | C24H25NO4 |
| 分子量 | 391.5 |
| 溶解度 | DMF: 12.5 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 uM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA , a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts. |
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