Amiprofos-methyl (BAY-NTN 6867) 是一种磷酰胺除草剂。
| Cas No. | 36001-88-4 |
| 别名 | 甲基胺草磷,BAY-NTN 6867 |
| 化学名 | N-(1-methylethyl)-phosphoramidothioic acid, O-methyl O-(4-methyl-2-nitrophenyl) ester |
| Canonical SMILES | CC1=CC([N+]([O-])=O)=C(OP(NC(C)C)(OC)=S)C=C1 |
| 分子式 | C11H17N2O4PS |
| 分子量 | 304.3 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Amiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM. |
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