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Setmelanotide TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Setmelanotide TFA图片
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Setmelanotide TFA (RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA) 是一种黑皮质素 4 受体 (MC4R) 激动剂,作用于人和大鼠黑皮质素 4 受体,EC50 分别为 0.27 nM 和 0.28 nM。
分子式C51H69F3N18O11S2
分子量1231.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Setmelanotide TFA (RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1]. EC50: 5.8 nM (hMC1R), 5.3 nM (hMC3R), 0.27 nM (hMC4R), 0.28 nM (rMC4R), 1600 nM (hMC5R)[1]Ki:3.9 nM (hMC1R), 10 nM (hMC3R), 2.1 nM (hMC4R), 430 nM (hMC5R), 2.7 nM (rMC4R)[1]

[1]. Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900.