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Tretinoin(Aberela)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tretinoin(Aberela)图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议
1g电议
5g电议

产品介绍
维甲酸 (Aberela) 是维生素 A 的代谢产物,在细胞生长、分化和器官发生中起重要作用。 Tretinoin (Aberela) 是 RAR 核受体的天然激动剂,对 RARα/β/γ 的 IC50 值为 14 nM。维甲酸 (Aberela) 与 PPARβ 结合;/δ; Kd 为 17 nM。维甲酸 (Aberela) 通过激活视黄酸受体 α 作为转录因子 Nrf2 的抑制剂。

Cell lines

Mesangial cell

Preparation Method

Mesangial cells were treated with Tretinoin (Aberela) at different concentrations.

Reaction Conditions

0 ~ 25 µm Tretinoin (Aberela); 0 to 24 hours

Applications

Tretinoin (Aberela) increased catalase activity and decreased glutathione levels in a dose-and time-dependent manner, thereby preventing H2O2 -induced cell injury. In glomerular mesangial cells, Tretinoin (Aberela) increased catalase mRNA and γ-glutamylcysteine synthetase (catalytic subunit) mRNA levels.

Animal models

Male Fischer 344 rats

Preparation Method

The difference between the control group and the experimental group(Tretinoin (Aberela)) was observed

Dosage form

1 mg/kg/day Tretinoin (Aberela); Oral medicine

Applications

In male Fischer 344 rats, Tretinoin (Aberela) at 1 mg/kg/day did not cause any toxic effects. Renal cortical protein levels were lower in Tretinoin (Aberela) -treated rats than in control animals of comparable age.

产品描述

Tretinoin (Aberela) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators[5].

In cultured human mesangial cells, Tretinoin (Aberela) increased the reduced glutathione content and the catalase activity in a dose- and time-dependent way, which then prevented the cytotoxicity of H2O2[1].A549 cells were incubated with free Tretinoin (Aberela) (TTN), blank nanocapsules (LNC) and Tretinoin (Aberela) -loaded lipid-core nanocapsules (TTN-LNC). TTN-LNC induced apoptosis and cell cycle arrest at the G1-phase while TTN did not. TTN-LNC showed higher cytotoxic effects than TTN on A549 cells evaluated[4].The combination of As-ODN-hTR and All-trans Tretinoin (Aberela) has a synergistic anti-tumor effect. This anti-tumor effect can be mainly attributed to apoptosis induced by a decrease in telomerase activity. Bcl-2 plays an important role in this process[7].

In male nmri mice, Tretinoin (Aberela) significantly inhibited cellular immunity and increased humoral immunity. Tretinoin (Aberela) decreased lymphocyte proliferation, decreased NBT, and interleukin-17 secretion, but increased interleukin-10 secretion[2]. In patients with facial acne, clindamycin phosphate Tretinoin (Aberela) Gel (CTG) (1.2% clindamycin phosphate, 0.025% Tretinoin (Aberela) in a gel base (Velac)) was significantly more effective than 0.025% Tretinoin (Aberela), which relayed on the anti-inflammatory efficacy of Tretinoin (Aberela)[3].The delivery of Tretinoin (Aberela) by polymeric micelles prolonged the blood circulation and enhanced the accumulation of Tretinoin (Aberela) in the tumor tissue compared with the administration of free Tretinoin (Aberela). Tumor growth was significantly delayed and the survival time of mice was prolonged following the treatment by Tretinoin (Aberela) polymeric micelles demonstrating the improved anticancer activity of Tretinoin (Aberela)[6].

References:
[1]: Manzano VM, Puyol MR, et,al. Tretinoin prevents age-related renal changes and stimulates antioxidant defenses in cultured renal mesangial cells. J Pharmacol Exp Ther. 1999 Apr;289(1):123-32. PMID: 10086995.
[2]: Froushani SM, Galeh HE. New insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice. Iran J Basic Med Sci. 2014 Sep;17(9):632-7. PMID: 25691937; PMCID: PMC4322144.
[3]: Richter JR, FOrstrOm LR, et,al. Efficacy of the fixed 1.2% clindamycin phosphate, 0.025% tretinoin gel formulation (Velac) and a proprietary 0.025% tretinoin gel formulation (Aberela) in the topical control of facial acne. J Eur Acad Dermatol Venereol. 1998 Nov;11(3):227-33. PMID: 9883434.
[4]: Schultze E, Ourique A, et,al. Encapsulation in lipid-core nanocapsules overcomes lung cancer cell resistance to tretinoin. Eur J Pharm Biopharm. 2014 May;87(1):55-63. doi: 10.1016/j.ejpb.2014.02.003. Epub 2014 Feb 11. PMID: 24525073.
[5]: Rhinn M, DollE P. Retinoic acid signalling during development. Development. 2012 Mar;139(5):843-58. doi: 10.1242/dev.065938. PMID: 22318625.
[6]: Chansri N, Kawakami S, et,al. Anti-tumor effect of all-trans retinoic acid loaded polymeric micelles in solid tumor bearing mice. Pharm Res. 2008 Feb;25(2):428-34. doi: 10.1007/s11095-007-9398-x. Epub 2007 Jul 31. PMID: 17665288.
[7]: Xu Q, Zhang Z, et,al. Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma. BMC Cancer. 2008 Jun 3;8:159. doi: 10.1186/1471-2407-8-159. PMID: 18522733; PMCID: PMC2427037.