CAS NO: | 1224925-76-1 |
包装: | 1mg |
市场价: | 4007元 |
Cas No. | 1224925-76-1 |
别名 | 格拉司琼-D3 |
Canonical SMILES | CN1[C@H]2C[C@H](NC(C3=NN(C([2H])([2H])[2H])C4=C3C=CC=C4)=O)C[C@@H]1CCC2 |
分子式 | C18H21D3N4O |
分子量 | 315.4 |
溶解度 | Methanol: Soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Granisetron-d3is intended for use as an internal standard for the quantification of granisetron by GC- or LC-MS. Granisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3(Ki= 3.9 nM) with antiemetic activity.1,2It is selective for 5-HT3over 5-HT4receptors (Ki= >1,000 nM).1Granisetron (0.3, 1, and 3 mg/kg, p.o.) increases the latency to a first vomiting episode and reduces the number of vomiting episodes in a canine model of emesis induced by cisplatin .2It also increases the latency to a first vomiting episode and reduces the number of vomiting and retching episodes in a ferret model of emesis induced by doxorubicin and cyclophosphamide when administered at doses of 0.1, 0.3, and 1 mg/kg. Formulations containing granisetron have been used in the prevention of nausea and vomiting associated with chemotherapy. 1.LÓpez-RodrÍguez, M.L., BenhamÚ, B., Morcillo, M.J., et al.Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptorsJ. Med. Chem.42(24)5020-5028(1999) 2.Haga, K., Inaba, K., Shoji, H., et al.The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesisJpn. J. Pharmacol.63(3)377-383(1993) |