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Galnon(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Galnon(trifluoroacetate salt)图片
CAS NO:1217448-19-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A galanin receptor agonist
Cas No.1217448-19-5
Canonical SMILESO=C(N[C@@H](CC1CCCCC1)C(N[C@H](C(NC2=CC(OC(C=C3C)=O)=C3C=C2)=O)CCCCN)=O)OCC4C(C=CC=C5)=C5C6=C4C=CC=C6.OC(C(F)(F)F)=O
分子式C40H46N4O6.CF3COOH
分子量792.9
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Galnon is a galanin (GAL) receptor agonist (KD= 2.9 µM in Bowes cells expressing GAL1receptors).1It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50= 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole . It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.2Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.3

1.Saar, K., Mazarati, A.M., Mahlapuu, R., et al.Anticonvulsant activity of a nonpeptide galanin receptor agonistProc. Natl. Acad. Sci. USA99(10)7136-7141(2002) 2.Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al.The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortexAddict. Biol.20(4)701-713(2015) 3.Abramov, U., FlorÉn, A., Echevarria, D.J., et al.Regulation of feeding by galnonNeuropeptides38(1)55-61(2004)