PGP-4008 是一种特异性 P-糖蛋白 (Pgp) 抑制剂。当与多柔比星联合给药时，PGP-4008 在小鼠同系 Pgp 介导的多药耐药 (MDR) 实体瘤模型中抑制肿瘤生长。
| Cas No. | 365565-02-2 |
| Canonical SMILES | O=C(CC1=CC=CC=C1)NC2=C(CCN3CC4=CC=CC=C4)C3=NC5=C2C=CC=C5 |
| 分子式 | C26H23N3O |
| 分子量 | 393.5 |
| 溶解度 | DMSO: 50mM,Ethanol: 5mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells. |
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