Nifekalant (hydrochloride) (MS-551) 是一种 III 类抗心律失常药物,是一种 IKr 钾通道阻滞剂,IC50 为 10 μM。
Cas No. | 130656-51-8 |
别名 | 盐酸尼非卡兰,MS-551 |
Canonical SMILES | OCCN(CCNC1=CC(N(C)C(N1C)=O)=O)CCCC2=CC=C([N+]([O-])=O)C=C2.Cl |
分子式 | C19H27N5O5•HCl |
分子量 | 441.9 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM). |