Nemadipine A 是 EGL-19 L 型 Ca2+ 通道的特异性抑制剂。 Nemadipine A 是一种可渗透细胞的 L 型钙通道抑制剂，可使 TRAIL 抗性癌细胞对该配体敏感。
| Cas No. | 54280-71-6 |
| Canonical SMILES | CC1=C(C(OCC)=O)C(C2=C(F)C(F)=C(F)C(F)=C2F)C(C(OCC)=O)=C(C)N1 |
| 分子式 | C19H18F5NO4 |
| 分子量 | 419.3 |
| 溶解度 | DMSO: 20 mg/ml,Ethanol: 15 mg/ml,Methanol: 100 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells. |
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