Fasentin 是一种有效的葡萄糖摄取抑制剂，可抑制 GLUT-1/GLUT-4 转运蛋白。
| Cas No. | 392721-37-8 |
| Canonical SMILES | ClC1=C(C(F)(F)F)C=C(NC(CC(C)=O)=O)C=C1 |
| 分子式 | C11H9ClF3NO2 |
| 分子量 | 279.6 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fasentin is an inhibitor of glucose transport. It partially inhibits glucose uptake in U937 and DU145 cells when used at concentrations ranging from 15 to 80 µM. Fasentin sensitizes PPC-1 prostate cancer and U937 leukemia cells, but not DU145 prostate cancer cells, to cell death induced by the Fas receptor activator CH-11 activating anti-Fas antibody (FAS). It also increases the expression of AspSyn and PCK2, genes associated with glucose deprivation, in PPC-1 cells and halts the cell cycle at the G0/G1 phase in U937 cells when used at concentrations of 50 and 40 µM, respectively. |
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