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Cholesteryl Myristate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cholesteryl Myristate图片
包装与价格:
包装价格(元)
500mg电议
1g电议

产品介绍
肉豆蔻酸胆固醇是一种存在于中药中的天然类固醇。 Cholesteryl Myristate 与几种离子通道结合,例如烟碱型乙酰胆碱受体、GABAA 受体和内向整流钾离子通道。

Cell experiment:

MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1].

产品描述

Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].

References:
[1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26.
[2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42.
[3]. Levitan I, et al. Cholesterol binding to ion channels. Front Physiol. 2014 Feb 26;5:65.