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Bongkrekic Acid(ammonium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bongkrekic Acid(ammonium salt)图片
CAS NO:11076-19-0
包装:100μg
市场价:2706元

产品介绍
Bongkrekic Acid（铵盐）是一种由 Pseudomonas cocovenenans 细菌分泌的线粒体毒素。
Cas No.11076-19-0
别名米酵菌酸,Bongkrek Acid
化学名(2E)-20-(carboxymethyl)-6R-methoxy-2,5,17S-trimethyl-2,4Z,8Z,10E,14E,18E,20Z-docosaheptaenedioic acid, triammonium salt
Canonical SMILESOC(/C=C(CC(O)=O)\C=C\[C@@H](C)C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(C)=C\C=C(C(O)=O)/C)=O.N.N.N
分子式C28H38O7•3NH3
分子量537.7
溶解度100mg/mL in DMSO, 1mg/mL in water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Bongkrekic acid is a natural toxin first isolated from coconut tempeh contaminated with bacteria. It is a polyunsaturated long-chain fatty acid derivative that acts as a potent inhibitor of the mitochondrial adenine nucleotide (ADP/ATP) translocase (Ki < 2 nM). [1][2][3]Despite its high affinity, bongkrekic acid has a slow rate of action in intact preparations, as it must permeate the inner mitochondrial membrane to bind the translocase.[3]

Reference:
[1]. Henderson, P.J.F., and Lardy, H.A. Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria. The Journal of Biological Chemisty 245(6), 1319-1326 (1970).
[2]. Dahout-Gonzalez, C., Hury, H., Trézéguet, V., et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).
[3]. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochimica et Biophysica Acta 1778(10), 1978-2021 (2008).