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U-51605
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
U-51605图片
CAS NO:64192-56-9
包装与价格：
包装价格(元)
100μg电议
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.64192-56-9
Canonical SMILESCCCCCC/C=C/[C@H]1C2N=NC(C2)[C@@H]1C/C=C\CCCC(O)=O
分子式C20H32N2O2
分子量332.5
溶解度DMF: >100 mg/ml (from U-46619),DMSO: >100 mg/ml (from U-46619),Ethanol: >100 mg/ml (from U-46619),PBS pH 7.2: >2 mg/ml (from U-46619)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM. At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA2 production and yet significantly increased PGE2 and PGF2α release.