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Phenidone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenidone图片
CAS NO:92-43-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议

产品介绍
Phenidone是一种具有口服活性的,环氧化酶(COX)和脂氧合酶(LOX)的双重抑制剂,可以改善实验性自身免疫性脑脊髓炎大鼠的瘫痪。Phenidone是一种对自发性高血压大鼠有效的降压剂。Phenidone用作照片显像剂。
Cas No.92-43-3
别名菲尼酮
Canonical SMILESO=C1NN(C2=CC=CC=C2)CC1
分子式C9H10N2O
分子量162.19
溶解度DMSO: 100 mg/mL (616.56 mM)
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].

Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].

Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].

[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.