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Ezetimibe phenoxy glucuronide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ezetimibe phenoxy glucuronide图片
CAS NO:190448-57-8
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Ezetimibephenoxyglucuronide(Ezetimibeglucuronide)是Ezetimibe的活性代谢物，具有抗高脂蛋白血症效果。Ezetimibe是有效的胆固醇吸收抑制剂。
Cas No.190448-57-8
别名依泽替米贝葡糖苷酸; Ezetimibe glucuronide; Ezetimibe β-D-glucuronide
Canonical SMILESO[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2
分子式C30H29F2NO9
分子量585.55
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].

[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.