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Thevetiaflavone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thevetiaflavone图片
CAS NO:29376-68-9
包装:5mg
市场价:7650元

产品介绍

Thevetiaflavone 可以上调 Bcl?2 的表达,下调 Bax 和 caspase-3 的表达。

Cas No.29376-68-9
别名黄花夹竹桃黄酮,Apigenin-5-methyl ether
Canonical SMILESO=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(OC)=C13
分子式C16H12O5
分子量284.26
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. Bcl-2 Bax Caspase-3

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic[1].

[1]. Yao H, et al. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS?mediated mitochondrial dysfunction. Mol Med Rep. 2017 Dec;16(6):9197-9202.