您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Mcl1-IN-9
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Mcl1-IN-9
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Mcl1-IN-9图片
CAS NO:1810769-31-3
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Mcl1-IN-9 是一种有效的髓细胞白血病基因 1 (Mcl-1) 抑制剂，在重组的 BCR-ABL+ B-ALL 细胞中的 IC50 值为 446 nM，Ki 值为 0.03 nM。
Cas No.1810769-31-3
Canonical SMILESO=C1C2=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=CC=CC(C5=C(C)N(C)N=C5C)=C4N2CCCN1CC6=CC=CC(C(O)=O)=C6
分子式C37H39ClN4O4
分子量639.18
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1]. Mcl-1|0.03 nM (Ki)

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].

[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.