Suberohydroxamic Acid

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

38937-66-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
500mg	电议
1g	电议

产品介绍

Suberohydroxamic Acid (Suberohydroxamic acid; SBHA) 是一种竞争性和细胞渗透性的 HDAC1 和 HDAC3 抑制剂，ID50 值分别为 0.25 μM 和 0.30 μM。Suberohydroxamic Acid 使 MM 细胞对凋亡敏感并促进线粒体凋亡途径。 Suberohydroxamic Acid 可用于甲状腺髓样癌 (MTC) 的研究。

Cas No.	38937-66-5
别名	软木肟酸,Suberohydroxamic acid; SBHA
化学名	N1,N8-dihydroxyoctanediamide
Canonical SMILES	ON([H])C(CCCCCCC(N(O)[H])=O)=O
分子式	C₈H₁₆N₂O₄
分子量	204.22
溶解度	>9.2mg/mL in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Suberohydroxamic Acid (Suberoyl bis-hydroxamic acid, SBHA) is an inhibitor of HDAC with ID50 values of 0.25 and 0.30 μM for HDAC1 and HDAC3, respectively [1]. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation. Suberohydroxamic Acid (SBHA) is an HDAC inhibitor. In MEL cells, SBHA induced the accumulation of acetylated H4 [1]. In medullary thyroid carcinoma (MTC) cells, SBHA dose-dependently induced the Notch-1 intracellular domain (the active form of Notch-1), which then decreased NE tumor marker chromogranin A (CgA) and achaete-scute complex-like 1 (ASCL-1), a downstream target of Notch-1 signaling. Also, SBHA increased the levels of cleaved poly ADP-ribose polymerase (PARP) and caspase-3, induced apoptosis and reduced cell viability in a dose-dependent way [2]. In MCF-7 breast cancer cells, SBHA induced the expressions of p53, p21, Bax, and PUMA, and ΔΨm collapsed, which then induced apoptosis [3]. In acute T lymphoblastic leukemia (T-ALL) cells, SBHA enhanced WNT/β-catenin signaling, blocked G2/M cell cycle progression, increased p21(WAF1) expression and inhibited cell growth. SBHA also increased the levels of cleaved PARP, caspase-9 and caspase-3, and induced apoptosis [4]. References: [1]. Richon VM, Emiliani S, Verdin E, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A, 1998, 95(6): 3003-3007. [2]. Ning L, Greenblatt DY, Kunnimalaiyaan M, et al. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist, 2008, 13(2): 98-104. [3]. Zhuang ZG, Fei F, Chen Y, et al. Suberoyl bis-hydroxamic acid induces p53-dependent apoptosis of MCF-7 breast cancer cells. Acta Pharmacol Sin, 2008, 29(12): 1459-1466. [4]. Shao N, Zou J, Li J, et al. Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia. Leuk Lymphoma, 2012, 53(9): 1769-1778.