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Triacetyl Resveratrol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Triacetyl Resveratrol图片
CAS NO:42206-94-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
25mg电议

产品介绍
三乙酰白藜芦醇，白藜芦醇的乙酰化类似物。三乙酰白藜芦醇在 PANC-1 和 BxPC-3 细胞中以剂量和时间依赖性方式降低 STAT3 和 NF-κB 的磷酸化。抗癌作用。
Cas No.42206-94-0
别名三乙酰基白藜芦醇
化学名(E)-5-(4-acetoxystyryl)-1,3-phenylene diacetate
Canonical SMILESCC(OC1=CC=C(C=C1)/C([H])=C([H])/C2=CC(OC(C)=O)=CC(OC(C)=O)=C2)=O
分子式C20H18O6
分子量354.35
溶解度≥ 13.85mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Triacetyl Resveratrol is a cell-permeable and more stable resveratrol prodrug [1].

Triacetyl Resveratrol is a potential and cell-permeable resveratrol prodrug. In 32D-cl3 cells, triacetyl resveratrol (3', 5',4'-Tri-O-acetylresveratrol) protected cells from irradiation and increased radioresistance, and is slightly more potent than resveratrol [1]. In lysates derived from HEK293-TYR cells, triacetyl resveratrol inhibited human TYR activity with IC50 value of 20 μM. In HEMs, triacetyl resveratrol was less cytotoxic than resveratrol. In both murine melanoma B16/F10 cells and HEMs, triacetyl resveratrol effectively inhibited intracellular melanin contents increased by α-MSH and L-tyrosine, respectively. Triacetyl Resveratrol was easily digested to resveratrol by esterases [2]. In LNCaP cells, triacetyl-resveratrol activated p53, increased p21 and p53R2 and decreased PSA expression. In CWR22Rv1 cells (mutated p53), triacetyl-resveratrol induced G1/S arrest [3]. In MCF-7 and MDA-MB-231 breast cancer cells, triacetyl-resveratrol interacted avidly and specifically with integrin αvβ3 through binding at the site targeted by the RGD peptide. Triacetyl-resveratrol induced ERK and p38 phosphorylation [4].

In γ-irradiated mice, 3,5,4'-Tri-O-acetylresveratrol (10 mg/kg) prior to γ-irradiation exhibited significant protective activity with 80% survival rate. Moreover, 3', 5',4'-Tri-O-acetylresveratrol had longer half-life that may assist more rapid distribution to tissues [1].

References:
[1].  Koide K, Osman S, Garner AL, et al. The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. ACS Med Chem Lett, 2011, 2(4): 270-274.
[2].  Park J, Park JH, Suh HJ, et al. Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis. Arch Dermatol Res, 2014, 306(5): 475-487.
[3].  Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis, 2011, 32(1): 93-101.
[4].  Hsieh TC, Wong C, John Bennett D, et al. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3. Int J Cancer, 2011, 129(11): 2732-2743.