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Rivaroxaban D4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rivaroxaban D4图片
CAS NO:1132681-38-9
包装与价格：
包装价格(元)
10mg电议
25mg电议

产品介绍
Rivaroxaban D4 (BAY 59-7939 D4) 是 Rivaroxaban 的氘代物。Rivaroxaban 是一种高效，选择性凝血因子 Xa (FXa) 抑制剂，IC50 为 0.7 nM，Ki 为 0.4 nM。
Cas No.1132681-38-9
别名5-氯-N-[[(5S)-2-氧代-3-[4-(3-氧代-4-吗啉基)苯基-2,3,5,6-D4]-5-恶唑烷基]甲基]-2-噻吩甲酰胺,BAY 59-7939-d4
Canonical SMILESO=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=C([2H])C([2H])=C(N4C(COCC4)=O)C([2H])=C3[2H])C(O2)=O
分子式C19H14D4ClN3O5S
分子量439.91
溶解度DMSO: Soluble
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rivaroxaban D4 (BAY 59-7939 D4) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2].

[1]. Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19) [2]. Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21.