Mizagliflozin

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Mizagliflozin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

666843-10-3

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
25mg	电议

产品介绍

Mizagliflozin (DSP-3235 free base) 是一种高效、口服、选择性的 SGLT1 抑制剂，对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 的对 SGLT1 选择性是 SGLT2 的 303 倍。Mizagliflozin 是一种抗糖尿病药物，可以改善餐后血糖波动。Mizagliflozin 在改善慢性便秘方面具有潜在的作用。

Cas No.	666843-10-3
别名	DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base
Canonical SMILES	O=C(N)C(C)(C)CNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C1
分子式	C₂₈H₄₄N₄O₈
分子量	564.67
溶解度	Methanol: 250 mg/mL (442.74 mM); DMSO: 100 mg/mL (177.09 mM)
储存条件	4℃, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1]. Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect[1].Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)[2] Animal Model: Male Wistar rats (rat model of low-fiber-diet-induced constipation)[1] [1]. Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. [2]. Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473.