您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Inz-1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Inz-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Inz-1图片
CAS NO:897776-15-7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Inz-1是一种有效的、选择性的酵母线粒体细胞色素bc1(mitochondrialcytochromebc1)抑制剂(IC50=8.092μM),优于对人的(IC50=45.320μM)。Inz-1逆转白色念珠菌对氟康唑或其他三唑抗真菌试剂的耐药性。
Cas No.897776-15-7
Canonical SMILESO=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3
分子式C16H14N2O2
分子量266.29
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole or other triazole antifungals' resistance in the pathogenic fungus Candida albicans[1].

Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose[1]. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively[1].Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC50 of 45.3 μM, 5.6-fold higher than the IC50 for the C. albicans homolog in mitochondria purified from HEK293 human embryonic kidney cells[1].Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM,and only mildly at that concentration[1].Inz-1 is against candida, human enzyme with IC50 values of 8.092 μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively[1].

[1]. Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991.