Friedelin

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Friedelin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

559-74-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Friedelin 是从 Maytenus ilicifolia(Mart) 的叶子中分离出来的。 Friedelin 是 CYP3A4 的非竞争性抑制剂，IC50 和 Ki 值分别为 10.79 μM 和 6.16 μM。 Friedelin 还是 CYP2E1 的竞争性抑制剂，IC50 和 Ki 值分别为 22.54 μM 和 18.02 μM。

Cas No.	559-74-0
别名	软木三萜酮
Canonical SMILES	C[C@@]12[C@]([C@@]3([H])[C@](C)(CCC(C)(C)C3)CC1)(CC[C@]4(C)[C@]2([H])CC[C@@]([C@H]5C)(C)[C@@]4([H])CCC5=O)C
分子式	C₃₀H₅₀O
分子量	426.72
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1]. [1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367.