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BI-2545
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BI-2545图片
CAS NO:2162961-71-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
BI-2545 是一种高效的 autotaxin (ATX) 抑制剂，可显著降低 LPA 的水平，对人和大鼠的 ATX 作用 IC50 值分别为 2.2 nM 和3.4 nM。
Cas No.2162961-71-7
Canonical SMILESO=C(N1C[C@]2([H])[C@H](CNC(C3=CC=C(NN=N4)C4=C3)=O)[C@]2([H])C1)OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5
分子式C23H19F6N5O3
分子量527.42
溶解度DMSO: 250 mg/mL (474.01 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC50s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively[1].

BI-2545 displays good potency in the LPA and rat whole blood assay with IC50s of 29 nM and 96 nM, respectively[1].

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs[1].BI-2545 (10 mg/kg; p.o.) has a half-life of t1/2=3.4 hours[1]. Animal Model: Rat[1]

[1]. Kuttruff, C. A., et al. Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo. ACS Medicinal Chemistry Letters, 8(12), 1252-1257.