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Ro 08-2750
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ro 08-2750图片
CAS NO:37854-59-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Ro 08-2750 是一种非肽和可逆的神经生长因子 (NGF) 抑制剂，与 NGF 结合，IC50 为 ~ 1 μM。
Cas No.37854-59-4
化学名7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
Canonical SMILESO=C1NC(N=C2N(C)C3=CC(C=O)=C(C)C=C3N=C21)=O
分子式C13H10N4O3
分子量270.24
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTRin PC12 cells when used at a concentration of 100 μM.[1] It also binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTRor tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.[2]

Reference:
[1]. Niederhauser, O., Mangold, M., Schubenel, R., et al. NGF ligand alters NGF signaling via p75NTR and trkA. J. Neurosci. Res. 61(3), 263-272 (2000).
[2]. Li, B., Cai, S., Zhao, Y., et al. Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway. Oncotarget 7(49), 81026-81048 (2016).