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Y 11
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Y 11图片
CAS NO:1086639-59-9
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Y 11 通过阻断 Y397 的磷酸化来抑制 FAK1 自身磷酸化并降低肿瘤生长。
Cas No.1086639-59-9
别名FAK Inhibitor 10
化学名1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide
Canonical SMILESOCC[N+]12CN3CN(C1)CN(C2)C3.[Br-]
分子式C8H17N4OBr
分子量265.15
溶解度10mg/mL in DMSO, 0.3mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397.[1] At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[1]

Reference:
[1]. Golubovskaya, V.M., Nyberg, C., Zheng, M., et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J. Med. Chem. 51(23), 7405-7416 (2008).