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QNZ(EVP4593 CAY10470)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QNZ(EVP4593 CAY10470)图片
CAS NO:545380-34-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
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25mg电议
50mg电议
100mg电议
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产品介绍
理化性质和储存条件
Molecular Weight (MW)356.42
FormulaC22H20N4O
CAS No.545380-34-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 5 mg/mL warming (14.0 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL (slightly soluble or insoluble)
Solubility (In vivo)0.5% hydroxyethyl cellulose: 30 mg/mL
Synonyms/Chemical NameCAY10470; CAY-10470; CAY 10470; EVP4593; EVP 4593; EVP-4593; 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
实验参考方法
In VitroEVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry.
In VivoEVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats.
Animal model male SD rats with carrageenin induced paw edema
Formulation & Dosage 0.5% hydroxypropyl cellulose; 1 mg/kg; i.p injection
References[1] Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391.
生物活性

Identification of EVP4593 in climbing assay screen with HD transgenic flies. Chem Biol. 2011 Jun 24;18(6):777-93

SOC pathway in WT and YAC128 MSNs - Ca2+ imaging assay. Chem Biol. 2011 Jun 24;18(6):777-93

Compounds from EVP4593 series or knockdown of TRPC1 protect YAC128 MSNs from glutamate-induced apoptosis. Chem Biol. 2011 Jun 24;18(6):777-93