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CK 869
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CK 869图片
CAS NO:388592-44-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
CK 869 是一种肌动蛋白相关蛋白 2/3 (ARP2/3) 复合物抑制剂，IC50 为 7 μM。
Cas No.388592-44-7
化学名2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one
Canonical SMILESCOC1=CC(OC)=C(N2C(CSC2C3=CC(Br)=CC=C3)=O)C=C1
分子式C17H16BrNO3S
分子量394.28
溶解度DMF: 1.5 mg/ml,DMSO: 2.5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].

References:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.
[2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.