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TMCB
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TMCB图片
CAS NO:905105-89-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
TMCB 是一种选择性的 ATP 竞争性 CK2（酪蛋白激酶 II）抑制剂，两种不同的催化 CK2 亚基 α 和 α' 的 Ki 值分别为 83 nM 和 21 nM。
Cas No.905105-89-7
别名4,5-二氢-N-(2,3,5,6-四溴-4-甲氧基苯基)-1H-咪唑-2-甲酰胺
化学名4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid
Canonical SMILESCN(C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1CC(O)=O)C
分子式C11H9Br4N3O2
分子量534.82
溶解度25mM in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 μM for both).[1] It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 μM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 μM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 μM.

Reference:
[1]. Pagano, M.A., Bain, J., Kazimierczuk, Z., et al. The selectivity of inhibitors of protein kinase CK2: An update. Biochem. J. 415(3), 353-365 (2008).