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Nutlin-3b
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nutlin-3b图片
CAS NO:675576-97-3
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)581.49
FormulaC30H30Cl2N4O4
CAS No.675576-97-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (172.0 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 100 mg/mL (172.0 mM)
SynonymsNutlin3b; Nutlin 3b; Nutlin-3b
Chemical Name2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
实验参考方法
In VitroNutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls.
In VivoN/A
Animal modelN/A
Formulation & DosageN/A
References[1] Vassilev LT, et al. Science, 2004, 303(5659), 844-848.
生物活性