| CAS NO: | 1364488-67-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 504.41 |
|---|---|
| Formula | C25H27Cl2N3O4 |
| CAS No. | 1364488-67-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (198.3 mM) |
| Water:<1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: 18 mg/mL (35.7 mM) | |
| Other info | Synonym: YH239-EE; YH239EE; YH239 EE; YH239 Ethylester; Chemical Name: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N InChi Code: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32) SMILES Code: O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC |
| Chemical Name | Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate |
| In Vitro | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). |
|---|---|
| In Vivo | N/A |
| Animal model | N/A |
| Formulation & Dosage | N/A |
| References | [1] Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811. |
 Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.
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