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RG-7112(RO-5045337)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RG-7112(RO-5045337)图片
CAS NO:939981-39-2
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)727.78
FormulaC38H48Cl2N4O4S
CAS No.939981-39-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (137.7 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: N/A
Solubility (In vivo)1% CMC Na:14 mg/mL
Chemical Name[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone
SynonymRG7112; RG-7112; RG 7112; RO5045337; RO 5045337; RO5045337
实验参考方法
In VitroRG7112 has been profiled extensively in many cell lines. In 15 cancer cell lines expressing wild-type p53, it shows IC50 in the range of 0.18 - 2.2 μM. However, the inhibition is much less in seven cancer cell lines with p53 mutation, IC50 5.7 - 20.3 μM. The overall selectivity is 14-fold.
In VivoIn the SJSA1 xenograft mouse model, RG7112 (200 mg/kg, p.o.) penetrates tumor cells and activate p53 and its 2 major functions, cell-cycle arrest and apoptosis. In nude mice bearing SJSA-1, and MHMn xenografts, RG7112 (100 mg/kg, p.o.) causes tumor regression. In rats, RG7112 impairs thrombopoiesis via activation of p53.
Animal model SJSA-1, SJSA-1luc2, and MHM xenografted Balb/c nude mice
Formulation & Dosage 1% Klucel LF/0.1% Tween 80; 200 mg/kg; oral taken
References[1]Pediatr Blood Cancer 2013;60:633–641
生物活性