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ML167
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML167图片
CAS NO:1285702-20-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
25mg电议

产品介绍
ML167 是一种高度选择性的 Cdc2 样激酶 4 (Clk4) 抑制剂,IC50 为 136 nM,对密切相关的激酶 Clk1、Clk2、Clk3 和 Dyrk1A/1B 的选择性 >10 倍。
Cas No.1285702-20-6
别名5-[4-[[(5-甲基-2-呋喃基)甲基]氨基]-6-喹唑啉基]-2-呋喃甲醇,CID44968231; NCGC00188654
Canonical SMILESCC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO
分子式C19H17N3O3
分子量335.36
溶解度≥ 16.75mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4) with IC50 value of 136nM [1].

The Clk family enzymes play their roles in gene splicing via phosphorylating the major component of the spliceosome, SR proteins. Small molecule probes that target Clk’s can be used to study the modulating functions of these kinases in gene splicing. ML167 is found as the first fully selective inhibitor of Clk4 but not other related kinases including Clk1, Clk2 and Clk3 and Dyrk1A/1B. It is 10-fold more potent against Clk4 over other kinases. The treatment of ML167 on Caco-2 cells proves that ML167 is highly cell-permeable. Besides that, ML167 is also found to be an ATP-competitive inhibitor [1].

References:
[1] Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.