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Poloxime
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Poloxime图片
CAS NO:17302-61-3
包装:1g
市场价:3035元

产品介绍
Poloxime 是 poloxin 的水解产物,是一种非 ATP 竞争性 Plk1 抑制剂,具有中等的 Plk1 抑制活性。
Cas No.17302-61-3
化学名(Z)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone
Canonical SMILESCC(C1=C/C(C(C)=CC1=O)=N/O)C
分子式C10H13NO2
分子量179.22
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1)[2].

References:
[1]. Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4.
[2]. Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.