您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Doxazosin Mesylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Doxazosin Mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxazosin Mesylate图片
CAS NO:77883-43-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议

产品介绍
Doxazosin mesylate (UK 33274) 是一种喹唑啉衍生物,可选择性拮抗突触后 α1-肾上腺素能受体。
Cas No.77883-43-3
别名甲磺酸多沙唑嗪; UK 33274 mesylate
化学名[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid
Canonical SMILESCOC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O
分子式C23H25N5O5.CH4O3S
分子量547.58
溶解度≥ 13.7mg/mL in DMSO with gentle warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Doxazosin Mesylate is a selective, long-lasting antagonist of α1-adrenergic receptor [1].

Doxazosin Mesylate has been reported to potentiate contraction response to 5-HT in a dose-dependent manner [1]. Doxazosin significantly reduced alcohol drinking and increased water intake in adult male P rats [2].

Studies has indicated that doxazosin could inhibit TNF-α expression in LPS-induced systemic inflammation model as well as reduce the MCP-1 production in LPS-induced pulmonary inflammation model. Additionally, Doxazosin decreased thickness of footpad in the delayed-type hypersensitivity mice model. Doxazosin had been reported to slightly reduce MCP-1 level in the peritoneal cavity of mice induced by thioglycollate [3].

References:
[1] Zhao Y1, Cao XB, Ren LM. Doxazosin selectively potentiates contraction to serotonin via 5-HT2A receptors in longitudinal muscle strips of the rabbit gastric body. Can J Physiol Pharmacol. 2014 Mar;92(3):197-204.
[2] O'Neil ML1, Beckwith LE, Kincaid CL, Rasmussen DD. The α1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats. Alcohol Clin Exp Res. 2013 Feb;37(2):202-12.
[3] Tung D1, Ciallella J, Cheung PH, Saha S. Novel anti-inflammatory effects of doxazosin in rodent models of inflammation. Pharmacology. 2013;91(1-2):29-34.