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Diazepinomicin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Diazepinomicin图片
CAS NO:733035-26-2
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
Diazepinomicin (TLN-4601) 是Micromonospora sp 的次生代谢产物，可抑制EGF 诱导的 Ras-ERK MAPK 信号通路，可诱导凋亡。是一种可用于 K-Ras 突变型的抗肿瘤药物。
Cas No.733035-26-2
别名ECO-4601; TLN-4601; BU 4664L
Canonical SMILESO=C1C2=CC=CC(O)=C2NC3=C(O)C=C(O)C=C3N1C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
分子式C28H34N2O4
分子量462.58
溶解度Soluble in DMSO
储存条件Store at -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1]. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway post Ras prenylation and prior to MEK activation[1].

[1]. Campbell PM, et al. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal. 2010 Nov 2;5:18.