您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Mefenamic acid D4
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Mefenamic acid D4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Mefenamic acid D4图片
CAS NO:1216745-79-7
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
MefenamicacidD4是Mefenamicacid的氘代物。Mefenamicacid是一种非甾体抗炎剂，为竞争性的hCOX-1和hCOX-2抑制剂，IC50值分别为40nM和3μM。
Cas No.1216745-79-7
别名甲芬那酸 D4
Canonical SMILESO=C(O)C1=C(NC2=CC=CC(C)=C2C)C([2H])=C([2H])C([2H])=C1[2H]
分子式C15H11D4NO2
分子量245.31
溶解度DMSO: Slightly soluble,Methanol: Slightly soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.